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Fundementals Of The Diploma Course

The great advances of 20th century medicine has its origins in the understanding of chemical behavior within the human organism. This gave rise to the pharmacological paradigm developed by Paul Eirich.

In this paradigm, the body responds as a set of chemical reactions, where the elements reach their entropy and harmony. This therapy is based on destruction, replacement or antagonistic biological phenomena through drugs, surgery and radiation therapy. However, the cell complex interactions were blurred in this context.

Advances in cell biology, typical of the late 20th and early 21st century, have given rise to a new form of medical therapy where cells and tissues are used as healing elements not only to supplement or replace the deficient cells, but to induce restoration of a lost biological order during the development of the disease.

In the opinion of many scientists, cell therapy has become the “arch medical” point around the structure of future medicine. It is the task and duty of this University to academically help lead this process, giving professionals the art of healing, as well as the scientific and practical methodologies concerning this new discipline.

Maimonides University since 2000, through Dr. Sarnaquiaro, and since his death with the help of Dr. Gustavo Moviglia have generated basic science and medical applications, not only to enrich this specialty, but help establish their own philosophy. Therefore, the issuance of a postgraduate course aims to create academic space for the training of professionals and gestation of new knowledge in this area of medicine.

Aims

The aim of the Diploma Program in Cell Therapy and Tissue Engineering is to train high academic level professionals capable to research and apply the knowledge of cell therapy and tissue engineering to different areas of medicine and dentistry. It is intended that the trainee should incorporate specific knowledge of the subject content and develop the ability to formulate and solve problems in their everyday professional practice. Within the program core competencies include the development and implementation of critical thinking and cooperative learning skills. Knowing the what, how, and why of cell therapy. And most importantly the ethical practice of cellular medicine. Knowledge in cell biology and understanding the mode of action and effectiveness of different cell therapies. Understand the role of the immune system in different cell therapies.

Contents

Unit I: Introduction to the study of somatic cell therapy and tissue engineering. Definitions, History, and Therapeutic Paradigm. Types of Somatic Cell Therapies and Bioethical issues. Unit II: Cell Biology Cell Structure and Functions. Cell and Tissue Growth. Cell Differentiation. Genetic and Epigenetic Regulation. Interaction of cells with other cells and extracellular matrix, humeral microenvironment. Development of these interactions during embryogenesis, tissue regeneration, tissue repair and cancer. Unit III: Immunology Humeral and Cellular Immunity. Innate and acquired immunity. Interactions. Effector function. Immune tolerance. Trophic and Reconstructive function. Unit IV: Biology of embryo development and normal and pathological tissue repair. Overview embryonic and fetal post-natal development. Genetic and epigenetic factors that influence growth, embryonic fetal and postnatal development. Maintenance and repair process of cells, tissue and organs. Genetic and epigenetic factors that interact and influence these processes. Identify certain cellular therapies that repair or correct defects. The Oncogenesis as a defect of genetic and epigenetic deregulation. Cell therapies aimed at correcting these deregulations. Unit V: Method of production, processing and application of biological drugs for Cell Therapy and Tissue Engineering. Sources of the cells used in cell therapy. Enforcement of cell techniques. Complex manipulation processes, GMP Standards. Cell processing laboratories. The Biosafety and quality of cellular products: Identity, Purity, Power, Security. Cell administration. Implant techniques. Evaluating the results of cell therapy. Layout of clinical trials. Teaching Techniques

Educational strategies will be taught in theory and in practical hands-on classes, in which the students can raise questions and work on problem solving. Practical work will be first carried out on animals, laboratory practices will be taught, and finally demonstration of therapies on humans.

Evaluation Each student will prepare an academic record which shall set forth as follows: - Set of Quizzes - Written exam. - Thesis.

The diploma will have a written exam to be taken on the last day, with a score of 0-10, and a passing grade minimum of 7 out of 10 points. Evaluations will be complemented with the development of a thesis, to be graded as pass or fail and must be supported with an oral examination.

Approval requirements of the Diploma

For the approval of the diploma the student must have 80% attendance in class, write a thesis and support it with an oral evaluation. A final exam will be given with a minimum passing grade of 70%

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